Two sample MR report

Telomere_length against HippSubfield lh volume CA4-head

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0332788	0.0994049	0.7411121
Weighted median	23	0.0169722	0.0578132	0.7690874
Inverse variance weighted	23	-0.0335940	0.0388452	0.3871379
Simple mode	23	0.0445858	0.1068325	0.6804722
Weighted mode	23	0.0520999	0.0862321	0.5519027

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.78403	21	0.6626277
Inverse variance weighted	18.31816	22	0.6869669

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.004106	0.0056181	0.4729507

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005778	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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