Two sample MR report

Telomere_length against HippSubfield lh volume CA4-body

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0934225	0.1261309	0.4670896
Weighted median	23	-0.0707648	0.0607351	0.2439628
Inverse variance weighted	23	-0.0128390	0.0491066	0.7937438
Simple mode	23	-0.0551382	0.1197526	0.6497232
Weighted mode	23	-0.0551382	0.0779575	0.4868145

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.80981	21	0.0379739
Inverse variance weighted	35.15846	22	0.0372930

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0065244	0.0071286	0.3704534

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010687	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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