Two sample MR report

Telomere_length against HippSubfield lh volume CA3-head

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1591557	0.0994028	0.1242875
Weighted median	23	-0.0360817	0.0567342	0.5247911
Inverse variance weighted	23	-0.0646809	0.0388447	0.0958899
Simple mode	23	-0.0609477	0.0967702	0.5353001
Weighted mode	23	-0.0193924	0.0861740	0.8240276

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.35565	21	0.9554055
Inverse variance weighted	12.42176	22	0.9480467

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0058008	0.0056181	0.313571

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004604	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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