Two sample MR report

Telomere_length against HippSubfield lh volume CA3-body

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0881048	0.1098753	0.4316141
Weighted median	23	-0.0305234	0.0634307	0.6303688
Inverse variance weighted	23	-0.0409111	0.0435443	0.3474596
Simple mode	23	0.0145162	0.0914215	0.8752886
Weighted mode	23	-0.0048562	0.0708300	0.9459583

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.65654	21	0.2198488
Inverse variance weighted	27.64460	22	0.1877602

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0079215	0.0062099	0.216016

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008713	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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