Two sample MR report

Telomere_length against HippSubfield lh volume CA1-head

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0014130	0.1253786	0.9911145
Weighted median	23	0.0224656	0.0589046	0.7029138
Inverse variance weighted	23	-0.0194580	0.0478964	0.6845566
Simple mode	23	0.0240759	0.1145681	0.8354888
Weighted mode	23	-0.0070288	0.0734126	0.9245907

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.40857	21	0.0418785
Inverse variance weighted	33.44746	22	0.0558508

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001108	0.0070861	0.8772451

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010211	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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