Two sample MR report

Telomere_length against HippSubfield lh volume CA1-body

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1037063	0.1266410	0.4220398
Weighted median	23	0.0117518	0.0653753	0.8573416
Inverse variance weighted	23	-0.0285546	0.0498101	0.5664627
Simple mode	23	0.0856592	0.1235860	0.4954907
Weighted mode	23	0.0664366	0.0816049	0.4242983

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.08433	21	0.0354932
Inverse variance weighted	36.17369	22	0.0290897

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0081208	0.0071575	0.2693318

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011125	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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