Two sample MR report

Telomere_length against Brainstem global volume Whole-brainstem

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0401331	0.1491234	0.7904587
Weighted median	23	-0.0508890	0.0564669	0.3674725
Inverse variance weighted	23	-0.0410069	0.0574055	0.4750190
Simple mode	23	-0.0992707	0.0958793	0.3117429
Weighted mode	23	-0.0739015	0.0611991	0.2400390

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	47.26039	21	0.0008662
Inverse variance weighted	48.04675	22	0.0010697

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0049819	0.008428	0.5607531

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014896	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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