Two sample MR report

Telomere_length against Brainstem global volume SCP

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0089460	0.1296058	0.9456228
Weighted median	23	0.0724444	0.0638903	0.2568418
Inverse variance weighted	23	0.0394380	0.0496765	0.4272550
Simple mode	23	0.1599866	0.1195392	0.1944477
Weighted mode	23	0.1405413	0.1121518	0.2233123

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.70086	21	0.0236178
Inverse variance weighted	35.98049	22	0.0305128

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0029708	0.0073251	0.6891637

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011215	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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