Two sample MR report

Telomere_length against Brainstem global volume Pons

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0053057	0.1476236	0.9716693
Weighted median	23	-0.0737623	0.0598012	0.2174046
Inverse variance weighted	23	-0.0391842	0.0565048	0.4880167
Simple mode	23	-0.0703044	0.0932351	0.4588121
Weighted mode	23	-0.0703044	0.0591141	0.2470003

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	46.31462	21	0.0011603
Inverse variance weighted	46.55104	22	0.0016787

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0027316	0.0083433	0.7466015

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014413	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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