Two sample MR report

Telomere_length against Brainstem global volume Midbrain

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0361926	0.1409717	0.7998806
Weighted median	23	-0.0496264	0.0578988	0.3913770
Inverse variance weighted	23	-0.0283422	0.0541373	0.6006093
Simple mode	23	-0.0131285	0.0920854	0.8879286
Weighted mode	23	-0.0407828	0.0648091	0.5356495

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	42.23395	21	0.0039318
Inverse variance weighted	42.73138	22	0.0050916

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0039624	0.0079673	0.6241239

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001311	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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