Two sample MR report

Telomere_length against Brainstem global volume Medulla

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1608761	0.1249206	0.2118176
Weighted median	23	-0.0291039	0.0564448	0.6061221
Inverse variance weighted	23	-0.0491409	0.0513426	0.3385079
Simple mode	23	-0.1079356	0.0993946	0.2892660
Weighted mode	23	-0.0524382	0.0608510	0.3981219

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.16461	21	0.0444234
Inverse variance weighted	38.43282	22	0.0163751

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0128949	0.0070602	0.0820365

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012131	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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