Two sample MR report

Telomere_length against BA-exvivo rh volume perirhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0084271	0.0997198	0.9334529
Weighted median	23	-0.0300740	0.0538931	0.5768233
Inverse variance weighted	23	-0.0274990	0.0388461	0.4790089
Simple mode	23	-0.0025995	0.0774248	0.9735188
Weighted mode	23	-0.0143640	0.0603382	0.8140393

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.13212	21	0.4509015
Inverse variance weighted	21.17556	22	0.5099120

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001171	0.0056359	0.8374057

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006569	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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