Two sample MR report

Telomere_length against BA-exvivo rh volume entorhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0272603	0.1193604	0.8215551
Weighted median	23	-0.0260877	0.0542467	0.6305818
Inverse variance weighted	23	-0.0195488	0.0455757	0.6679745
Simple mode	23	0.0379358	0.0831757	0.6527941
Weighted mode	23	-0.0165818	0.0548942	0.7654371

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.27589	21	0.0865826
Inverse variance weighted	30.28299	22	0.1117468

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0004735	0.006746	0.9447082

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009253	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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