Two sample MR report

Telomere_length against BA-exvivo rh volume V2

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1818439	0.1390515	0.2050960
Weighted median	23	0.0122424	0.0679126	0.8569434
Inverse variance weighted	23	-0.0148241	0.0551987	0.7882696
Simple mode	23	0.0747063	0.1430008	0.6066003
Weighted mode	23	0.0249504	0.0911054	0.7867444

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.09105	21	0.0054635
Inverse variance weighted	44.42284	22	0.0031390

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.010255	0.0078589	0.2060482

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013505	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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