Two sample MR report

Telomere_length against BA-exvivo rh volume V1

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0841841	0.1124530	0.4623917
Weighted median	23	0.0245941	0.0585109	0.6742412
Inverse variance weighted	23	0.0131071	0.0438277	0.7648938
Simple mode	23	-0.0084440	0.1117177	0.9404336
Weighted mode	23	0.0882303	0.0842305	0.3062475

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.87454	21	0.1750445
Inverse variance weighted	28.00511	22	0.1755121

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0059737	0.0063556	0.3579502

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000852	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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