Two sample MR report

Telomere_length against BA-exvivo rh volume MT

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0904298	0.1097765	0.4193318
Weighted median	23	-0.0235983	0.0556029	0.6712680
Inverse variance weighted	23	-0.0029429	0.0427550	0.9451227
Simple mode	23	-0.0585850	0.0949376	0.5435101
Weighted mode	23	-0.0169796	0.0612784	0.7842977

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.60921	21	0.2217431
Inverse variance weighted	26.65048	22	0.2248031

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.005733	0.0062043	0.3659593

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008078	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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