Two sample MR report

Telomere_length against BA-exvivo rh volume BA6

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1871435	0.1435566	0.2064735
Weighted median	23	-0.0931325	0.0597173	0.1188645
Inverse variance weighted	23	-0.0504984	0.0561864	0.3687775
Simple mode	23	-0.1570552	0.1014883	0.1360037
Weighted mode	23	-0.1112827	0.0664877	0.1083435

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.79654	21	0.0024841
Inverse variance weighted	46.02666	22	0.0019620

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00839	0.0081135	0.3128619

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014458	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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