Two sample MR report

Telomere_length against BA-exvivo rh volume BA4p

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1643195	0.1337514	0.2328337
Weighted median	23	-0.0721207	0.0585131	0.2177411
Inverse variance weighted	23	-0.0296639	0.0524994	0.5720505
Simple mode	23	-0.0938396	0.0829499	0.2701187
Weighted mode	23	-0.0724697	0.0596899	0.2375810

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.01778	21	0.0128269
Inverse variance weighted	40.18341	22	0.0102904

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0082677	0.0075592	0.2864628

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012352	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8