Two sample MR report

Telomere_length against BA-exvivo rh volume BA4a

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1512737	0.1146488	0.2012232
Weighted median	23	-0.0673886	0.0560086	0.2289056
Inverse variance weighted	23	-0.0222100	0.0453038	0.6239601
Simple mode	23	-0.0197208	0.0995501	0.8447868
Weighted mode	23	-0.0510097	0.0636045	0.4311415

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.93360	21	0.1420447
Inverse variance weighted	29.92309	22	0.1203457

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0079244	0.0064796	0.2348868

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009166	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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