Two sample MR report

Telomere_length against BA-exvivo rh volume BA45

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0748930	0.1209157	0.5423268
Weighted median	23	0.0026456	0.0553422	0.9618720
Inverse variance weighted	23	-0.0287925	0.0463530	0.5344966
Simple mode	23	0.0401135	0.1081332	0.7142125
Weighted mode	23	-0.0582500	0.0670492	0.3943551

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.07157	21	0.0724751
Inverse variance weighted	31.32540	22	0.0896467

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0028306	0.0068338	0.6829303

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009658	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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