Two sample MR report

Telomere_length against BA-exvivo rh volume BA44

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2784273	0.1078726	0.0174224
Weighted median	23	-0.0806587	0.0611200	0.1869428
Inverse variance weighted	23	-0.0943663	0.0444272	0.0336648
Simple mode	23	-0.0276098	0.1156086	0.8134546
Weighted mode	23	-0.0888444	0.0819197	0.2898723

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.73108	21	0.2589992
Inverse variance weighted	28.77770	22	0.1513176

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0113015	0.0060968	0.0778869

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010508	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8