Two sample MR report

Telomere_length against BA-exvivo rh volume BA3b

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1883719	0.1213788	0.1356191
Weighted median	23	-0.1022464	0.0579248	0.0775372
Inverse variance weighted	23	-0.0821439	0.0473282	0.0826308
Simple mode	23	-0.0790067	0.1025739	0.4493489
Weighted mode	23	-0.1093202	0.0652813	0.1081708

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.30960	21	0.0686575
Inverse variance weighted	32.65737	22	0.0668588

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0065224	0.00686	0.3525323

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011251	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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