Two sample MR report

Telomere_length against BA-exvivo rh volume BA3a

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1011336	0.1334191	0.4568656
Weighted median	23	-0.0210312	0.0568010	0.7111877
Inverse variance weighted	23	-0.0433330	0.0512059	0.3974142
Simple mode	23	-0.0410026	0.1056214	0.7015968
Weighted mode	23	-0.0369133	0.0636320	0.5677371

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.82885	21	0.0134966
Inverse variance weighted	38.22787	22	0.0172719

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0035489	0.0075405	0.6427435

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001196	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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