Two sample MR report

Telomere_length against BA-exvivo rh volume BA2

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1444968	0.0994074	0.1608442
Weighted median	23	-0.0769678	0.0590265	0.1922497
Inverse variance weighted	23	-0.0661112	0.0388458	0.0887766
Simple mode	23	-0.0289508	0.0983942	0.7713386
Weighted mode	23	-0.0832768	0.0666425	0.2245752

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.86024	21	0.4675075
Inverse variance weighted	21.59408	22	0.4843287

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0048129	0.0056183	0.401312

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007421	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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