Two sample MR report

Telomere_length against BA-exvivo rh volume BA1

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2599048	0.1024622	0.0191950
Weighted median	23	-0.1753655	0.0538614	0.0011305
Inverse variance weighted	23	-0.1205572	0.0411022	0.0033559
Simple mode	23	-0.1601203	0.0924228	0.0971871
Weighted mode	23	-0.1767255	0.0609444	0.0083095

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.31156	21	0.3817505
Inverse variance weighted	24.63081	22	0.3150533

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.008556	0.005791	0.1543912

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010383	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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