Two sample MR report

Telomere_length against BA-exvivo rh thickness perirhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1285211	0.1165907	0.2827931
Weighted median	23	-0.0513263	0.0579037	0.3753982
Inverse variance weighted	23	-0.0603665	0.0449389	0.1791741
Simple mode	23	-0.0514167	0.0985908	0.6072183
Weighted mode	23	-0.0899837	0.0703433	0.2141520

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.88817	21	0.1167124
Inverse variance weighted	29.44296	22	0.1326435

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0041847	0.0065894	0.5322489

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009653	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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