Two sample MR report

Telomere_length against BA-exvivo rh thickness entorhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0188189	0.1276802	0.8842293
Weighted median	23	0.0615209	0.0552808	0.2657593
Inverse variance weighted	23	0.0293008	0.0489410	0.5493749
Simple mode	23	0.1260141	0.0891581	0.1715385
Weighted mode	23	0.0655391	0.0579323	0.2701087

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.64405	21	0.0308802
Inverse variance weighted	34.92060	22	0.0394914

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0029545	0.0072162	0.6863686

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010753	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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