Two sample MR report

Telomere_length against BA-exvivo rh thickness V2

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2438183	0.1168872	0.0493690
Weighted median	23	-0.0832012	0.0582177	0.1529644
Inverse variance weighted	23	-0.0226562	0.0489104	0.6432070
Simple mode	23	-0.0502110	0.1060674	0.6406000
Weighted mode	23	-0.0876116	0.0635559	0.1819077

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.03509	21	0.1131615
Inverse variance weighted	34.87703	22	0.0399064

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0135793	0.0066062	0.0524724

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010672	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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