Two sample MR report

Telomere_length against BA-exvivo rh thickness V1

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1654040	0.0994076	0.1109856
Weighted median	23	-0.0600325	0.0547450	0.2728239
Inverse variance weighted	23	0.0002579	0.0388462	0.9947025
Simple mode	23	-0.0430546	0.0879544	0.6293256
Weighted mode	23	-0.0503428	0.0642892	0.4419354

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.48878	21	0.8905418
Inverse variance weighted	16.76650	22	0.7761140

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0101716	0.0056183	0.0845596

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005081	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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