Two sample MR report

Telomere_length against BA-exvivo rh thickness MT

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0845139	0.1224992	0.4978024
Weighted median	23	-0.0795560	0.0552992	0.1502510
Inverse variance weighted	23	-0.0491887	0.0468782	0.2940464
Simple mode	23	-0.0158061	0.0915250	0.8644686
Weighted mode	23	-0.1008917	0.0609660	0.1121456

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.89008	21	0.0600672
Inverse variance weighted	32.03912	22	0.0767315

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.002169	0.0069234	0.757157

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010194	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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