Two sample MR report

Telomere_length against BA-exvivo rh thickness BA6

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1408433	0.1272571	0.2809142
Weighted median	23	0.0108880	0.0592062	0.8540922
Inverse variance weighted	23	-0.0097993	0.0500125	0.8446589
Simple mode	23	0.0854542	0.1121951	0.4543528
Weighted mode	23	0.0461081	0.0854595	0.5949391

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.41609	21	0.0326896
Inverse variance weighted	36.46715	22	0.0270426

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0080461	0.0071923	0.2758973

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011069	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8