Two sample MR report

Telomere_length against BA-exvivo rh thickness BA4p

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2567764	0.1427142	0.0863694
Weighted median	23	-0.0471245	0.0611914	0.4412306
Inverse variance weighted	23	-0.0144946	0.0587341	0.8050764
Simple mode	23	-0.0743399	0.1003887	0.4668144
Weighted mode	23	-0.0743399	0.0643167	0.2601443

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.28486	21	0.0028905
Inverse variance weighted	50.29600	22	0.0005348

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.014876	0.0080658	0.0792914

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015282	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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