Two sample MR report

Telomere_length against BA-exvivo rh thickness BA4a

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2491517	0.1064441	0.0291966
Weighted median	23	-0.0404099	0.0561503	0.4717259
Inverse variance weighted	23	-0.0329492	0.0451055	0.4650895
Simple mode	23	-0.0090697	0.1046815	0.9317407
Weighted mode	23	-0.0472795	0.0712918	0.5141028

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.07913	21	0.2892405
Inverse variance weighted	29.66210	22	0.1269111

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0132748	0.006016	0.0386125

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009206	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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