Two sample MR report

Telomere_length against BA-exvivo rh thickness BA45

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0185123	0.1014107	0.8569039
Weighted median	23	0.0310020	0.0582207	0.5943864
Inverse variance weighted	23	-0.0095437	0.0388457	0.8059274
Simple mode	23	0.1454454	0.1071883	0.1885684
Weighted mode	23	0.0093193	0.0732076	0.8998592

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.85518	21	0.4078964
Inverse variance weighted	21.94919	22	0.4629251

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0017226	0.0057315	0.7667087

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000667	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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