Two sample MR report

Telomere_length against BA-exvivo rh thickness BA44

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0203038	0.1050252	0.8485637
Weighted median	23	-0.0014544	0.0590564	0.9803517
Inverse variance weighted	23	0.0187633	0.0402532	0.6411214
Simple mode	23	0.0416429	0.0888035	0.6437309
Weighted mode	23	-0.0017343	0.0632444	0.9783698

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.44053	21	0.3209476
Inverse variance weighted	23.62281	22	0.3673068

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0023987	0.0059358	0.6902177

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007229	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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