Two sample MR report

Telomere_length against BA-exvivo rh thickness BA3b

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1667355	0.1052462	0.1280832
Weighted median	23	-0.1237366	0.0548334	0.0240335
Inverse variance weighted	23	-0.0503594	0.0415397	0.2253902
Simple mode	23	-0.0943229	0.0925308	0.3191082
Weighted mode	23	-0.1072327	0.0686010	0.1322921

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.53994	21	0.3158791
Inverse variance weighted	25.15752	22	0.2896013

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0071455	0.0059483	0.2430208

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008132	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8