Two sample MR report

Telomere_length against BA-exvivo rh thickness BA3a

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1326222	0.1122159	0.2504764
Weighted median	23	-0.0263104	0.0551129	0.6330837
Inverse variance weighted	23	0.0070291	0.0446686	0.8749599
Simple mode	23	-0.1568779	0.1117443	0.1743079
Weighted mode	23	-0.0347716	0.0684643	0.6165919

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.76048	21	0.1789228
Inverse variance weighted	29.08975	22	0.1423161

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0085745	0.0063422	0.1907613

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008825	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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