Two sample MR report

Telomere_length against BA-exvivo rh thickness BA2

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2205552	0.0994066	0.0376589
Weighted median	23	-0.0430108	0.0516605	0.4050891
Inverse variance weighted	23	-0.0352800	0.0388457	0.3637676
Simple mode	23	-0.0566377	0.0962799	0.5623479
Weighted mode	23	-0.0961818	0.0610860	0.1296367

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.42061	21	0.8931787
Inverse variance weighted	17.52047	22	0.7340109

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0113759	0.0056183	0.0557879

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005559	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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