Two sample MR report

Telomere_length against BA-exvivo rh area perirhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0873566	0.1071228	0.4239504
Weighted median	23	-0.0339241	0.0588303	0.5641804
Inverse variance weighted	23	-0.0311222	0.0422810	0.4616817
Simple mode	23	-0.0138808	0.1000586	0.8909280
Weighted mode	23	-0.0616688	0.0832347	0.4665877

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.38669	21	0.2747018
Inverse variance weighted	26.06324	22	0.2489766

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0072746	0.0060543	0.2429144

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008092	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8