Two sample MR report

Telomere_length against BA-exvivo rh area entorhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0021640	0.1311500	0.9869909
Weighted median	23	-0.0521046	0.0564046	0.3556084
Inverse variance weighted	23	-0.0425584	0.0502353	0.3968939
Simple mode	23	-0.0071259	0.1009471	0.9443614
Weighted mode	23	-0.0678529	0.0629565	0.2928107

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.55352	21	0.0189321
Inverse variance weighted	36.79240	22	0.0249266

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0027459	0.0074123	0.7147511

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011512	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8