Two sample MR report

Telomere_length against BA-exvivo rh area V2

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0516805	0.1301728	0.6953629
Weighted median	23	0.0895237	0.0633864	0.1578470
Inverse variance weighted	23	0.0048877	0.0499617	0.9220675
Simple mode	23	0.1094547	0.1435477	0.4538615
Weighted mode	23	0.1327603	0.0963244	0.1819794

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.01157	21	0.0217999
Inverse variance weighted	36.39377	22	0.0275418

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0034733	0.0073572	0.6417234

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011033	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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