Two sample MR report

Telomere_length against BA-exvivo rh area V1

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0133798	0.1156686	0.9090101
Weighted median	23	0.0136532	0.0614541	0.8241822
Inverse variance weighted	23	0.0152739	0.0441621	0.7294474
Simple mode	23	-0.0824957	0.1249761	0.5160471
Weighted mode	23	-0.0784584	0.1229151	0.5298586

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.43409	21	0.1282641
Inverse variance weighted	28.43451	22	0.1617243

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0001163	0.0065374	0.9859743

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008663	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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