Two sample MR report

Telomere_length against BA-exvivo rh area MT

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1349867	0.1105605	0.2356437
Weighted median	23	0.0466084	0.0545459	0.3928395
Inverse variance weighted	23	0.0349514	0.0431707	0.4181651
Simple mode	23	-0.0298591	0.0893503	0.7414085
Weighted mode	23	0.0360085	0.0617605	0.5657996

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.97618	21	0.2073588
Inverse variance weighted	27.17134	22	0.2047908

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0061421	0.0062486	0.3368173

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008479	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8