Two sample MR report

Telomere_length against BA-exvivo rh area BA6

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0798845	0.1099725	0.4756105
Weighted median	23	-0.0434819	0.0551583	0.4305157
Inverse variance weighted	23	-0.0392766	0.0421467	0.3513879
Simple mode	23	-0.0984340	0.0869283	0.2696748
Weighted mode	23	-0.0573163	0.0618688	0.3642817

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.70062	21	0.2180951
Inverse variance weighted	25.89756	22	0.2561062

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0024933	0.0062154	0.6923609

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008157	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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