Two sample MR report

Telomere_length against BA-exvivo rh area BA4p

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0854889	0.1039329	0.4200123
Weighted median	23	0.0373205	0.0539804	0.4893323
Inverse variance weighted	23	0.0089127	0.0402812	0.8248874
Simple mode	23	-0.0694258	0.0943363	0.4695420
Weighted mode	23	0.0239906	0.0636750	0.7099562

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.95548	21	0.3463567
Inverse variance weighted	23.65583	22	0.3655254

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0047017	0.005874	0.4324249

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007184	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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