Two sample MR report

Telomere_length against BA-exvivo rh area BA4a

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0762448	0.0994073	0.4516227
Weighted median	23	0.0611064	0.0550564	0.2670470
Inverse variance weighted	23	0.0124196	0.0388458	0.7491835
Simple mode	23	0.0974157	0.0919386	0.3008337
Weighted mode	23	0.0746054	0.0696693	0.2958444

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.59463	21	0.5470514
Inverse variance weighted	20.08116	22	0.5779626

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0039188	0.0056183	0.4931291

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006116	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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