Two sample MR report

Telomere_length against BA-exvivo rh area BA45

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0788914	0.1256594	0.5368903
Weighted median	23	-0.0727081	0.0560972	0.1949381
Inverse variance weighted	23	-0.0244855	0.0482277	0.6116592
Simple mode	23	-0.0714900	0.0975024	0.4711698
Weighted mode	23	-0.0952629	0.0658778	0.1622586

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.55688	21	0.0403954
Inverse variance weighted	33.91042	22	0.0501640

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0033405	0.007102	0.6429436

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010395	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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