Two sample MR report

Telomere_length against BA-exvivo rh area BA44

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2537849	0.0994043	0.0185200
Weighted median	23	-0.1540801	0.0578975	0.0077849
Inverse variance weighted	23	-0.1096041	0.0397689	0.0058508
Simple mode	23	-0.1288884	0.1035632	0.2263971
Weighted mode	23	-0.1565626	0.0762732	0.0521889

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.57577	21	0.4850989
Inverse variance weighted	23.05874	22	0.3984189

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0088528	0.0056182	0.1300306

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00094	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8