Two sample MR report

Telomere_length against BA-exvivo rh area BA3b

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0786763	0.1089702	0.4782584
Weighted median	23	-0.0066907	0.0606047	0.9120927
Inverse variance weighted	23	-0.0434861	0.0417252	0.2973183
Simple mode	23	-0.0143530	0.1111038	0.8983848
Weighted mode	23	0.0186240	0.0795250	0.8170024

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.23471	21	0.2371419
Inverse variance weighted	25.38261	22	0.2791302

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0021607	0.0061588	0.7292107

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008071	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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