Two sample MR report

Telomere_length against BA-exvivo rh area BA3a

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0000585	0.1161769	0.9996032
Weighted median	23	0.0271146	0.0589729	0.6456742
Inverse variance weighted	23	-0.0389294	0.0444944	0.3816126
Simple mode	23	-0.0309606	0.1032221	0.7670372
Weighted mode	23	0.0455138	0.0736404	0.5428856

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.68311	21	0.1218197
Inverse variance weighted	28.86357	22	0.1487974

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0023867	0.0065661	0.7198754

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000905	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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